EIF2AK2 CLIA Kit for Human(Homo sapiens) | EIAab.comEIF2AK2 CLIA Kit for Human(Homo sapiens)

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EIF2AK2 (Gene name),

Interferon-induced, double-stranded RNA-activated protein kinase (Protein name ), E2AK2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

EIF2AK2(PKR;PRKR);

Protein name:

Interferon-induced, double-stranded RNA-activated protein kinase;

Alternative:

Interferon-inducible RNA-dependent protein kinase;Eukaryotic translation initiation factor 2-alpha kinase 2(eIF-2A protein kinase 2);Protein kinase RNA-activated(PKR);P1/eIF-2A protein kinase;p68 kinase;2.7.10.2;Tyrosine-protein kinase EIF2AK2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with STRBP (By similarity). Interacts with DNAJC3. Inhibited by direct interaction with viral proteins such as HCV E2, HCV NS5A and influenza A NS1. Activated by the interaction with HIV-1 Tat (By similarity). Forms a complex with FANCA, FANCC, FANCG and HSP70.

Function:

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In adddition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

551

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

551:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.131431

MIM:

176871

STRING:

9606.ENSP00000233057

KEGG:

hsa:5610

Pfam:

PF00035

SMR:

P19525

String:

P19525

Uniprot:

P19525

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ELISA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase

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E1135r

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96T

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ELISA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase

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E1135h

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ELISA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase

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E1135m

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CLIA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135h

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96T

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CLIA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Interferon-induced, double-stranded RNA-activated protein kinase

Cat.:

U1135r

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96T

Polyclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase

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P1135Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase

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P1135Rb-m

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Polyclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase

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P1135Rb-h

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Packing:

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Monoclonal Antibody for Human Interferon-induced, double-stranded RNA-activated protein kinase

Protein for Human Interferon-induced, double-stranded RNA-activated protein kinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon."
Meurs E. , Chong K. , Galabru J. , Thomas N.S.B. , Kerr I.M. , Williams B.R.G. , Hovanessian A.G.
Cell62:379-390(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 101-118 AND 309-325;INDUCTION
2.

Meurs E.
Submitted (1990-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells."
Thomis D.C. , Doohan J.P. , Samuel C.E.
Virology188:33-46(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones."
Kuhen K.L. , Shen X. , Samuel C.E.
Gene178:191-193(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
5.

"Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-dependent protein kinase (PKR) and differences from its mouse homolog."
Kuhen K.L. , Shen X. , Carlisle E.R. , Richardson A.L. , Weier H.-U.G. , Tanaka H. , Samuel C.E.
Genomics36:197-201(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Placenta.
6.

"Genomic features of human PKR: alternative splicing and a polymorphic CGG repeat in the 5'-untranslated region."
Xu Z. , Williams B.R.
J. Interferon Cytokine Res.18:609-616(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

Li H. , Huang F. , Shen C. , Zhou G. , Zheng G. , Ke R. , Lin L. , Yang S.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Embryo.
9.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
10.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
13.

Bienvenut W.V. , Gao M. , Leug H.
Submitted (2009-06) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-18; 27-40; 70-77; 414-426 AND 430-440;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Prostatic carcinoma.
14.

"The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity."
Polyak S.J. , Tang N. , Wambach M. , Barber G.N. , Katze M.G.
J. Biol. Chem.271:1702-1707(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNAJC3
15.

"The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR."
Brand S.R. , Kobayashi R. , Mathews M.B.
J. Biol. Chem.272:8388-8395(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
16.

"Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein."
Gale M.J. Jr. , Korth M.J. , Tang N.M. , Tan S.-L. , Hopkins D.A. , Dever T.E. , Polyak S.J. , Gretch D.R. , Katze M.G.
Virology230:217-227(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV NS5A
17.

"Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase."
Tan S.L. , Katze M.G.
J. Interferon Cytokine Res.18:757-766(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INFLUENZA A NS1 PROTEIN
18.

"Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein."
Taylor D.R. , Shi S.T. , Romano P.R. , Barber G.N. , Lai M.M.C.
Science285:107-110(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV E2 ENVELOPE PROTEIN
19.

"PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex."
Bonnet M.C. , Weil R. , Dam E. , Hovanessian A.G. , Meurs E.F.
Mol. Cell. Biol.20:4532-4542(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IKBKB
20.

"Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression."
Daher A. , Longuet M. , Dorin D. , Bois F. , Segeral E. , Bannwarth S. , Battisti P.-L. , Purcell D.F. , Benarous R. , Vaquero C. , Meurs E.F. , Gatignol A.
J. Biol. Chem.276:33899-33905(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TARBP2
21.

"Hepatitis C virus envelope protein E2 does not inhibit PKR by simple competition with autophosphorylation sites in the RNA-binding domain."
Taylor D.R. , Tian B. , Romano P.R. , Hinnebusch A.G. , Lai M.M.C. , Mathews M.B.
J. Virol.75:1265-1273(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-83; THR-88; THR-89; THR-90; SER-242; THR-255 AND THR-258;MUTAGENESIS OF SER-83; THR-88; THR-89; THR-90; SER-242; THR-255; THR-258 AND LYS-296;INHIBITION BY HCV E2 ENVELOPE PROTEIN
22.

"Binding of double-stranded RNA to protein kinase PKR is required for dimerization and promotes critical autophosphorylation events in the activation loop."
Zhang F. , Romano P.R. , Nagamura-Inoue T. , Tian B. , Dever T.E. , Mathews M.B. , Ozato K. , Hinnebusch A.G.
J. Biol. Chem.276:24946-24958(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS;PHOSPHORYLATION AT THR-446 AND THR-451
23.

"Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase."
Burysek L. , Pitha P.M.
J. Virol.75:2345-2352(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HHV-8 PROTEIN VIRF2
24.

"The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain."
Cassady K.A. , Gross M.
J. Virol.76:2029-2035(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HHV-1 US11
25.

"Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR."
Pang Q. , Christianson T.A. , Koretsky T. , Carlson H. , David L. , Keeble W. , Faulkner G.R. , Speckhart A. , Bagby G.C.
J. Biol. Chem.278:41709-41717(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NPM1;ENZYME REGULATION
26.

"Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation."
Silva A.M. , Whitmore M. , Xu Z. , Jiang Z. , Li X. , Williams B.R.
J. Biol. Chem.279:37670-37676(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP2K6
27.

"The Fanconi anemia proteins functionally interact with the protein kinase regulated by RNA (PKR)."
Zhang X. , Li J. , Sejas D.P. , Rathbun K.R. , Bagby G.C. , Pang Q.
J. Biol. Chem.279:43910-43919(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH FANCA; FANCC; FANCG AND HSP70
28.

"TRAF family proteins link PKR with NF-kappa B activation."
Gil J. , Garcia M.A. , Gomez-Puertas P. , Guerra S. , Rullas J. , Nakano H. , Alcami J. , Esteban M.
Mol. Cell. Biol.24:4502-4512(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRAF2; TRAF5 AND TRAF6;SUBCELLULAR LOCATION
29.

"Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L."
Langland J.O. , Jacobs B.L.
Virology324:419-429(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INHIBITION BY VACCINIA VIRUS PROTEIN E3
30.

"Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action."
Garcia M.A. , Gil J. , Ventoso I. , Guerra S. , Domingo E. , Rivas C. , Esteban M.
Microbiol. Mol. Biol. Rev.70:1032-1060(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
31.

"Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase."
Su Q. , Wang S. , Baltzis D. , Qu L.K. , Wong A.H. , Koromilas A.E.
Proc. Natl. Acad. Sci. U.S.A.103:63-68(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-101; TYR-162 AND TYR-293
32.

"Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection."
Nie Y. , Hammond G.L. , Yang J.H.
J. Virol.81:917-923(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADAR
33.

"Activation of PKR: an open and shut case?"
Cole J.L.
Trends Biochem. Sci.32:57-62(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION
34.

"Nck-1 interacts with PKR and modulates its activation by dsRNA."
Cardin E. , Larose L.
Biochem. Biophys. Res. Commun.377:231-235(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCK1;ENZYME REGULATION
35.

"Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR."
Mittelstadt M. , Frump A. , Khuu T. , Fowlkes V. , Handy I. , Patel C.V. , Patel R.C.
Nucleic Acids Res.36:998-1008(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DUS2L;ENZYME REGULATION
36.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83 AND SER-456;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
37.

"PKR activity is required for acute leukemic cell maintenance and growth: a role for PKR-mediated phosphatase activity to regulate GSK-3 phosphorylation."
Blalock W.L. , Grimaldi C. , Fala F. , Follo M. , Horn S. , Basecke J. , Martinelli G. , Cocco L. , Martelli A.M.
J. Cell. Physiol.221:232-241(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
38.

"An antiviral response directed by PKR phosphorylation of the RNA helicase A."
Sadler A.J. , Latchoumanin O. , Hawkes D. , Mak J. , Williams B.R.
PLoS Pathog.5:E1000311-E1000311(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DHX9
39.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
40.

"PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control."
Kang J.I. , Kwon S.N. , Park S.H. , Kim Y.K. , Choi S.Y. , Kim J.P. , Ahn B.Y.
Virus Res.142:51-56(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HCV RESTRICTION
41.

"A role for protein kinase PKR in the mediation of Epstein-Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression."
Lin S.S. , Lee D.C. , Law A.H. , Fang J.W. , Chua D.T. , Lau A.S.
Cytokine50:210-219(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
42.

"New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses."
Yoon C.-H. , Miah M.A. , Kim K.P. , Bae Y.-S.
EMBO Rep.11:393-399(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS CDK1 KINASE UPON DNA DAMAGE;FUNCTION AS TYROSINE-PROTEIN KINASE
43.

"Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense."
Harashima A. , Guettouche T. , Barber G.N.
Genes Dev.24:2640-2653(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
44.

"Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment."
Chang J.H. , Kato N. , Muroyama R. , Taniguchi H. , Guleng B. , Dharel N. , Shao R.X. , Tateishi K. , Jazag A. , Kawabe T. , Omata M.
Liver Int.30:311-318(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HCV RESTRICTION
45.

"The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells."
Yang X. , Nath A. , Opperman M.J. , Chan C.
Mol. Biol. Cell21:3449-3458(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-451
46.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
47.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
48.

"Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease."
Bose A. , Mouton-Liger F. , Paquet C. , Mazot P. , Vigny M. , Gray F. , Hugon J.
Brain Pathol.21:189-200(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION
49.

"Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response."
Pfaller C.K. , Li Z. , George C.X. , Samuel C.E.
Curr. Opin. Immunol.23:573-582(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
50.

"The role of protein kinase R in the interferon response."
Pindel A. , Sadler A.
J. Interferon Cytokine Res.31:59-70(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
51.

"Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress."
Blalock W.L. , Bavelloni A. , Piazzi M. , Tagliavini F. , Faenza I. , Martelli A.M. , Follo M.Y. , Cocco L.
Leukemia25:236-245(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION
52.

"PKR-dependent mechanisms of interferon-? for inhibiting hepatitis B virus replication."
Park I.H. , Baek K.W. , Cho E.Y. , Ahn B.Y.
Mol. Cells32:167-172(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HBV RESTRICTION
53.

"The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest."
Bennett R.L. , Pan Y. , Christian J. , Hui T. , May W.S. Jr.
Cell Cycle11:407-417(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
54.

"Penetration resistance: PKR's other talent."
Lacy-Hulbert A. , Stuart L.M.
Immunity36:695-696(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
55.

"Protein kinase PKR amplification of interferon beta induction occurs through initiation factor eIF-2alpha-mediated translational control."
McAllister C.S. , Taghavi N. , Samuel C.E.
J. Biol. Chem.287:36384-36392(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
56.

"Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity."
Shen S. , Niso-Santano M. , Adjemian S. , Takehara T. , Malik S.A. , Minoux H. , Souquere S. , Marino G. , Lachkar S. , Senovilla L. , Galluzzi L. , Kepp O. , Pierron G. , Maiuri M.C. , Hikita H. , Kroemer R. , Kroemer G.
Mol. Cell48:667-680(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH STAT3
57.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
58.

"Novel role of PKR in inflammasome activation and HMGB1 release."
Lu B. , Nakamura T. , Inouye K. , Li J. , Tang Y. , Lundbaeck P. , Valdes-Ferrer S.I. , Olofsson P.S. , Kalb T. , Roth J. , Zou Y. , Erlandsson-Harris H. , Yang H. , Ting J.P. , Wang H. , Andersson U. , Antoine D.J. , Chavan S.S. , more...
Nature488:670-674(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NLRP1; NLRP3; NLRC4 AND AIM2;AUTOPHOSPHORYLATION
59.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
60.

"PKR-dependent inflammatory signals."
Kang R. , Tang D.
Sci. Signal.5:PE47-PE47(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
61.

"Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection."
Taghavi N. , Samuel C.E.
Virology427:208-216(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
62.

"dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection."
Dabo S. , Meurs E.F.
Viruses4:2598-2635(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
63.

"PKR regulates proliferation, differentiation and survival of murine hematopoietic stem/progenitor cells."
Liu X. , Bennett R.L. , Cheng X. , Byrne M. , Reinhard M.K. , May W.S. Jr.
Blood121:3364-3374(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
64.

"The eIF2alpha kinases: their structures and functions."
Donnelly N. , Gorman A.M. , Gupta S. , Samali A.
Cell. Mol. Life Sci.70:3493-3511(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
65.

"Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation."
Okumura F. , Okumura A.J. , Uematsu K. , Hatakeyama S. , Zhang D.E. , Kamura T.
J. Biol. Chem.288:2839-2847(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ISGYLATION AT LYS-69 AND LYS-159;ENZYME REGULATION
66.

"Toscana virus NSs protein promoftes degradation of double-stranded RNA-dependent protein kinase."
Kalveram B. , Ikegami T.
J. Virol.87:3710-3718(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TOS NSS;ENZYME REGULATION
67.

"Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1."
Okonski K.M. , Samuel C.E.
J. Virol.87:756-766(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MV RESTRICTION
68.

"Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsrna-stimulated human lung epithelial cells."
Li Y. , Xie J. , Wu S. , Xia J. , Zhang P. , Liu C. , Zhang P. , Huang X.
PLoS ONE8:E55108-E55108(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
69.

"The modulation of hepatitis C virus 1a replication by PKR is dependent on NF-kB mediated interferon beta response in Huh7.5.1 cells."
Zhang L. , Alter H.J. , Wang H. , Jia S. , Wang E. , Marincola F.M. , Shih J.W. , Wang R.Y.
Virology438:28-36(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HCV RESTRICTION
70.

"Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dsRNA-mediated activation."
Nanduri S. , Carpick B.W. , Yang Y. , Williams B.R.G. , Qin J.
EMBO J.17:5458-5465(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-175
71.

"Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR."
Dar A.C. , Dever T.E. , Sicheri F.
Cell122:887-900(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 258-550 IN COMPLEX WITH EIF2ALPHA;PHOSPHORYLATION AT THR-446
72.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-428; VAL-439 AND VAL-506

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